This is a nice simple exercise using pretty much just a rubber stamp tool and not a lot else. Take a photo, make 2 copies of the same photo, open the copied version, make 10 changes, pop them both into Publisher with a title on the top of "SPOT THE 10 DIFFERENCES". Job done!!!

Fireworks MX
cone  Spot the difference video instructions - Fireworks MX 

 

  Fireworks CS6
cone  Spot the difference video instructions - Fireworks CS6